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16Neville ECorris PAVivian JNariman SGibson GJNebulised salbutamol and anginaBr Med JClin Res Ed2851982796-7.

RESULTSAdverse event reporting rates were similar for the three treatment groupsThe morning PEF tended to be lower for the Proventil HFA and Ventolin groups than the HFA-134a placebo groupbut the evening PEF tended to be higher for the active treatment groupsDaytime asthma symptom scores tended to be lowerbetterwith active treatment than placebobut nighttime asthma sleep disturbance scores were similar for all three treatment groupsUse of Ventolin Rotacaps as rescue medication was significantly greater for the HFA-134a placebo group than the Proventil HFA and Ventolin groupsDiary card data did not change within groups over timeInvestigator global assessments of asthma scores clustered between fair and good for all three treatment groups throughout the studyChanges in heart rate and BP were small after dosing with study drug and tended to be similar for the active treatments and HFA-134a placebo groupsNo clinically meaningful changes in results of standard laboratory tests were found in any treatment group during this study.

28Yates DHKharitonov SABarnes PJAn inhaled glucocorticoid does not prevent tolerance to the bronchoprotective effect of a long-acting inhaled beta(2agonistAm J Respir Crit Care Med 15419961603-7.

Albuterol may cause allergic reactionsStop using the medicine and check with your doctor right away if you or your child develop a skin rashhivesitchingswellingor any type of allergic reaction after taking this medicine.

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