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Tabl 7: Tatmnt-mgnt Advs vnts Congstiv Hat ailu (CH) in Patints with NYHA Class II III Congstiv Hat ailu Tatd with Pioglitazon Glybuid.

Postmakting pots congstiv hat ailu hav bn potd in patints tatd with pioglitazon, both with and without pviously known hat disas and both with and without concomitant insulin administation.

Thiazolidindions, including pioglitazon, which is a componnt ACTOPLUS MT, caus xacbat congstiv hat ailu in som patints [s WANINGS AND PCAUTIONS]. At initiation ACTOPLUS MT, and at dos incass, monitpatints caully signs and symptoms hat ailu (.g., xcssiv, apid wight gain, dyspna, and/dma). I hat ailu dvlops, it should b managd accoding tcunt standads ca and discontinuation dos duction ACTOPLUS MT must b considd [s WANINGS AND PCAUTIONS]. ACTOPLUS MT is not commndd in patints with symptomatic hat ailu. Initiation ACTOPLUS MT in patints with stablishd Nw Yok Hat Association (NYHA) Class III IV hat ailu is containdicatd [s CONTAINDICATIONS and WANINGS AND PCAUTIONS].

Clinical studis dmonstat that pioglitazon impovs insulin snsitivity in insulin-sistant patints. Pioglitazon nhancs cllula sponsivnss tinsulin, incass insulin-dpndnt glucos disposal and impovs hpatic snsitivity tinsulin. In patints with typ 2 diabts, th dcasd insulin sistanc poducd by pioglitazon sults in low plasma glucos concntations, low plasma insulin concntations, and low HbA1c valus. In contolld clinical tials, pioglitazon had an additiv ct on glycmic contol whn usd in combination with a sulonylua, mtomin, insulin [s Clinical Studis ].

NOT: paticipants should not stat homonal thapy th pupos mting th ligibility citia this potocol Ability tundstand and th willingnss tsign a wittn inomd consnt documnt.

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